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The Knowledge Discovery Engine®
A Powerful, General, Classification Algorithm

Overview of Publications

Correlogic has published landmark papers using the KDE that demonstrate:

  • cancer can be diagnosed by patterns in mass spectrometry profiles of serum [13]
  • this includes the identification of informative patterns in high resolution mass spectrometric data that may lead to diagnostic tests for ovarian, prostate, breast, and pancreatic cancer [4, 7, 8, 11, 12]
  • the identification of patterns gauging the state of remission in Wegener's granulomatosis [6]
  • the identification of patterns distinguishing metastatic from benign pheochromocytoma [5]
  • the discrimination between preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse [10]
  • pattern recognition for toxicogenomics of drug induced cardiac toxicities and cardioprotection [9]
  • the species-specific detection of bacillus spores [2]
  • the species-specific detection of bacteria [3]

List of Publications Using Correlogic Technology

  1. Mansfield BC, Krebs MD, Yip P, Cohen SJ, Sonenshein AL, Hitt BA, Davis CE. Novel technology for rapid species-specific detection of Bacillus spores. Biomol Eng 2006; 234: 119-127.
  2. Mansfield BC, Shnayderman M, Yip P, Clark HA, Krebs MD, Cohen SJ, Zeskind JE, Ryan ET, Dorkin HL, Callahan MV, Stair TO, Gelfand JA, Gill CJ, Hitt B, Davis CE. Species-specific bacteria identification using differential mobility spectrometry and bioinformatics pattern recognition. Anal Chem 2005; 15: 5930-5937.
  3. Mansfield B, Shriver CD, Yip P, Hitt B, Hooke J, Somiari S, Flynn J, Liebman M. A serum pattern predictive of breast cancer. J. Clin Oncol 2005; 23:848s (suppl, abstr 9545).
  4. Brouwers FM, Petricoin EF 3rd, Ksinantova L, Breza J, Rajapakse V, Ross S, Johann D, Mannelli M, Shulkin BL, Kvetnansky R, Eisenhofer G, Walther MM, Hitt BA, Conrads TP, Veenstra TD, Mannion DP, Wall MR, Wolfe GM, Fusaro VA, Liotta LA, Pacak K. Low molecular weight proteomic information distinguishes metastatic from benign pheochromocytoma. Endocr Relat Cancer 2005; 12(2):263-72.
  5. Stone JH, Rajapakse VN, Hoffman GS, Specks U, Merkel PA, Spiera RF, Davis JC, St Clair EW, McCune J, Ross S, Hitt BA, Veenstra TD, Conrads TP, Liotta LA, Petricoin EF 3rd; Wegener's Granulomatosis Etanercept Trial Research Group. A serum proteomic approach to gauging the state of remission in Wegener's granulomatosis. Arthritis Rheum 2005; 52(3):902-10.
  6. Conrads TP, Fusaro VA, Ross S, Johann D, Rajapakse V, Hitt BA, Steinberg SM, Kohn EC, Fishman DA, Whitely G, Barrett JC, Liotta LA, Petricoin EF, 3rd, Veenstra TD. High-resolution serum proteomic features for ovarian cancer detection. Endocr Relat Cancer 2004; 11(2):163-78.
  7. Ornstein DK, Rayford W, Fusaro VA, Conrads TP, Ross SJ, Hitt BA, Wiggins WW, Veenstra TD, Liotta LA, Petricoin EF, 3rd. Serum proteomic profiling can discriminate prostate cancer from benign prostates in men with total prostate specific antigen levels between 2.5 and 15.0 ng/ml. J Urol 2004; 172(4 Pt 1):1302-5.
  8. Petricoin EF, Rajapaske V, Herman EH, Arekani AM, Ross S, Johann D, Knapton A, Zhang J, Hitt BA, Conrads TP, Veenstra TD, Liotta LA, Sistare FD. Toxicoproteomics: serum proteomic pattern diagnostics for early detection of drug induced cardiac toxicities and cardioprotection. Toxicol Pathol 2004; 32 Suppl 1:122-30.
  9. Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, Jacks T, Wright CV, Hruban RH, Lowy AM, Tuveson DA. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 2003; 4(6):437-50.
  10. Liotta LA, Petricoin EF, 3rd, Ardekani AM, Hitt BA, Levine PJ, Fusaro VA, Steinberg SM, Mills GB, Simone C, Fishman DA, Kohn EC. General keynote: proteomic patterns in sera serve as biomarkers of ovarian cancer. Gynecol Oncol 2003; 88(1 Pt 2): S25-8; discussion S37-42.
  11. Petricoin EF, 3rd, Ornstein DK, Paweletz CP, Ardekani A, Hackett PS, Hitt BA, Velassco A, Trucco C, Wiegand L, Wood K, Simone CB, Levine PJ, Linehan WM, Emmert-Buck MR, Steinberg SM, Kohn EC, Liotta LA. Serum proteomic patterns for detection of prostate cancer. J Natl Cancer Inst 2002; 94(20):1576-8.
  12. Petricoin EF, Ardekani AM, Hitt BA, Levine PJ, Fusaro VA, Steinberg SM, Mills GB, Simone C, Fishman DA, Kohn EC, Liotta LA. Use of proteomic patterns in serum to identify ovarian cancer. Lancet 2002; 359(9306):572-7.

Other Presentations Using Correlogic Technology

Yamada K, Yasuda M, Ishizuka H, Nishii M, Matsuzaki M, Furukawa M, Tanaka T. Proteomic Pattern Recognition in Serum to Diagnose Ovarian Cancer in a Japanese Sample Set - Preliminary Results. Poster 227, 11th Biennial International Gynecologic Cancer Society Meeting (IGCS): 2006: October 14 – 18, Santa Monica, CA.

Krebs MD, Mansfield B, Yip P, Cohen SJ, Hitt BA, Sonenshein AL, Davis CE. Detection and Differentiation of Bacillus Spores Using Pyrolysis – Differential Mobility Spectrometry and Genetic Algorithms. PittCon; 2006: Abs 2100-22 March 12-17, Orlando, FL.

Fishman DA, Hao Z, Van Pelt CK, Wiggins WS, Seshaiah P, Coleman TA, Hitt BA. High-throughput multidimensional mass spectrometry analysis for the detection of early stage epithelial ovarian cancer: A serum test for ovarian cancer. Society of Gynecologic Investigation; 2004: March 25, Houston, TX.

Hitt B. Application of Pattern Discovery Technology. IBC: Biomarker Identification. Molecular Diagnostic and Targeted Therapeutics Conference; 2003: May 28, Boston, MA.

Schultz GA, Zhang S, Howe K, Van Pelt CK, Hao Z, Henion JD, Petricoin EF, Liotta LA, Fusaro V, Ross S, Veenstra T, Conrads T, Fishman D, Wiggins WS, Coleman TA, Hitt BA. Development of a proteome marker model for ovarian cancer using direct analysis of diluted serum by automated nanoelectrospray tof-ms. ASMS; 2003: June 8-12, Montreal, Canada.

Hao Z, Howe K, Van Pelt CK, Smith D, Zhang S, Wiggins W, Hitt BA, Coleman TA. Application of chip-based, automated nanoelectrospray mass spectrometry for proteomic pattern recognition. CHI Protein Biomarkers Conference; 2003: August, Philadelphia, PA.

Overview | Applications / Classification | How it Works | Supporting Software | Publications

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